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Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis

Author:
  • Jun John Wu
  • Carl Ekman
  • Andreas Jönsen
  • Gunnar Sturfelt
  • Anders Bengtsson
  • Anders Gottsäter
  • Bengt Lindblad
  • Elisabet Lindqvist
  • Tore Saxne
  • Björn Dahlbäck
Publishing year: 2011
Language: English
Publication/Series: Arthritis Research and Therapy
Volume: 13
Issue: 2
Document type: Journal article
Publisher: BioMed Central

Abstract english

Introduction: Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family. These receptors can be shed from the cell membrane and their soluble extracellular regions can be found in plasma. The objective of this study was to elucidate whether the plasma levels of soluble Mer (sMer) and Tyro3 (sTyro3) were increased in systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), or critical limb ischemia (CLI). Methods: ELISA kits were used to test plasma concentrations in controls and in patients with SLE, RA or CLI. Results: Increased levels of, in particular, sMer and, to some extent, sTyro3, were found in patients with SLE or RA, but not in patients with CLI. Patients with SLE demonstrated the highest sMer levels and there was a strong correlation to higher SLE disease activity score (SLEDAI). In contrast, in patients with RA, the sMer levels did not correlate with the disease activity score (DAS). In SLE, sMer levels were particularly high in those with lupus nephritis, patients who also had decreased C1q levels and increased titers of anti-DNA antibodies. After therapy, the plasma concentrations of sMer decreased in parallel to the decrease in SLEDAI score. Conclusions: The plasma concentrations of sMer and sTyro3 were significantly increased in patients with active SLE and RA, suggesting the TAM receptor shedding was affected by these autoimmune diseases. In particular, sMer was increased in SLE, the plasma levels of sMer reflecting disease activity.

Keywords

  • Rheumatology and Autoimmunity

Other

Published
  • Clinical Chemistry, Malmö
  • Vascular Diseases - Clinical Research
  • ISSN: 1478-6362
E-mail: carl [dot] ekman [at] med [dot] lu [dot] se

Postdoctoral fellow

Genomics, Diabetes and Endocrinology

33

Research project participant

Genomics, Diabetes and Endocrinology

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00