Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Carina Törn

Coordinator

Default user image.

Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes

Author

  • A Scholin
  • Carina Törn
  • L Nystrom
  • C Berne
  • H Arnqvist
  • G Blohme
  • J Bolinder
  • JW Eriksson
  • I Kockum
  • Mona Landin-Olsson
  • J Ostman
  • FA Karlsson
  • Göran Sundkvist
  • E Bjork

Summary, in English

Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM). Methods In Sweden 362 patients (15-34 years) classified as Type 1 DM were,, included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA(1c) and insulin dosage over a median period after diagnosis of 5 years. Duration of remission defined, as an insulin maintenance dose less than or equal to 0.3 U/kg/24 h and HbA(1c) within the normal range, was analysed in relation to characteristics at diagnosis. Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1-73). Sixteen per cent had a remission with a duration > 12 months. Among patients with antibodies (ab(+)), bivariate analysis suggested that adult age, absence of low BMI, high plasma C-peptide concentrations, lack of ketonuria or ketoacidosis at diagnosis and low insulin dose at discharge from hospital were associated with a high possibility of achieving remission. Multiple regression showed that normal weight (BMI of 20-24.9 kg/m(2)) was the only factor that remained significant for the possibility of entering remission. In survival analysis among ab(+) remitters, a low number of islet antibodies, one or two instead of three or four, were associated with a long duration of remissions. Conclusion In islet antibody-positive Type 1 DM, normal body weight was the strongest factor for entering remission, whilst a low number of islet antibodies was of importance for the duration.

Department/s

  • Department of Clinical Sciences, Malmö
  • Medicine, Lund

Publishing year

2004

Language

English

Pages

447-455

Publication/Series

Diabetic Medicine

Volume

21

Issue

5

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Endocrinology and Diabetes

Keywords

  • Type 1 DM
  • remission
  • BMI
  • islet antibodies
  • young adults

Status

Published

ISBN/ISSN/Other

  • ISSN: 1464-5491