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Carina Törn

Coordinator

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Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes.

Author

  • Carina Törn
  • A Shtauvere-Brameus
  • C B Sanjeevi
  • Mona Landin-Olsson

Summary, in English

This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays. SOX13Ab were found in 9.8% (10/102) of type 1 patients compared to 2.0% (2/99) in healthy controls (P = 0.033). At least one of the four autoantibodies (ICA, GADA, IA-2A or SOX13Ab) were identified in 67% (68/102) of the patients. Samples positive for IA-2A were only in one case positive also for SOX13Ab. IA-2A-positive patients were often positive also for ICA and GADA (19/27), and the same combination was also common for SOX13Ab-positive patients (6/10). Only 2.0% (2/102) were positive for SOX13Ab alone. ICA, GADA and IA-2A were more frequent in younger patients (<or= 35 years of age) than in older patients, while SOX13Ab showed similar frequency in both groups. We concluded that the frequency of SOX13Ab was significantly increased in Swedish patients with type 1 diabetes, but that the addition of SOX13Ab to the combination of GADA and IA2-A only increased the sensitivity by 2% for autoimmune diabetes. Therefore, SOX13 could be a minor autoantigen involved in the pathogenesis of type 1 diabetes.

Department/s

  • Diabetes and Celiac Unit
  • Medicine, Lund

Publishing year

2002

Language

English

Pages

218-223

Publication/Series

Annals of the New York Academy of Sciences

Volume

958

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Other Clinical Medicine

Keywords

  • Diabetes Mellitus
  • Child
  • Autoantigens : immunology
  • Autoantigens : blood
  • Autoantibodies : immunology
  • Autoantibodies : blood
  • Aging : immunology
  • 80 and over
  • Aged
  • Adult
  • Adolescence
  • High Mobility Group Proteins : blood
  • High Mobility Group Proteins : immunology
  • Human
  • Middle Age
  • Support
  • Non-U.S. Gov't
  • Sweden : epidemiology
  • Insulin-Dependent : epidemiology
  • Insulin-Dependent : immunology

Status

Published

Research group

  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISSN: 0077-8923