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Carina Törn


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The Environmental Determinants of Diabetes in the Young (TEDDY) Study


  • Marian Rewers
  • Åke Lernmark
  • Daniel Agardh
  • Peter Almgren
  • Carin Andrén Aronsson
  • Maria Ask
  • Ulla-Marie Carlsson
  • Corrado Cilio
  • Jenny Bremer
  • Joanna Gerardsson
  • Barbro Gustavsson
  • Gertie Hansson
  • Ida Jönsson
  • Monica Hansen
  • Susanne Hyberg
  • Sten Ivarsson
  • Helena Larsson
  • Barbro Lernmark
  • Maria Markan
  • Marie Jessica Melin
  • Maria Månsson Martinez
  • Kobra Rahmati
  • Monica Sedig-Järvirova
  • Birgitta Sjöberg
  • Carina Törn
  • Anne Wallin
  • Ingrid Wigheden
  • Åsa Wimar

Other contributions

  • Steve Oberste

Summary, in English

The etiology of type 1 diabetes (T1D) remains unknown, but a growing body of evidence points to infectious agents and/or components of early childhood diet. The National Institutes of Health has established the TEDDY Study consortium of six clinical centers in the United States and Europe and a data coordinating center to identify environmental factors predisposing to, or protective against, islet autoimmunity and T1D. From 2004-2009, TEDDY will screen more than 360,000 newborns from both the general population and families already affected by T1D to identify an estimated 17,804 children with high-risk HLA-DR,DQ genotypes. Of those, 7,801 (788 first-degree relatives and 7,013 newborns with no family history of T1D) will be enrolled in prospective follow-up beginning before the age of 4.5 months. As of May 2008, TEDDY has screened more than 250,000 newborns and enrolled nearly 5,000 infants--approximately 70% of the final cohort. Participants are seen every 3 months up to 4 years of age, with subsequent visits every 6 months until the subject is 15 years of age. Blood samples are collected at each visit for detection of candidate infectious agents and nutritional biomarkers; monthly stool samples are collected for infectious agents. These samples are saved in a central repository. Primary endpoints include (1) appearance of one or more islet autoantibodies (to insulin, GAD65 or IA-2) confirmed at two consecutive visits; (2) development of T1D. By age 15, an estimated 800 children will develop islet autoimmunity and 400 will progress to T1D; 67 and 27 children have already reached these endpoints.


  • Celiac Disease and Diabetes Unit
  • Diabetes - Cardiovascular Disease
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Immunovirology
  • Paediatric Endocrinology

Publishing year







Annals of the New York Academy of Sciences



Document type

Journal article




  • Endocrinology and Diabetes


  • Adolescent
  • Autoantibodies/analysis
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1/epidemiology
  • Environment
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Immunologic Techniques/standards
  • Infant
  • Mass Screening
  • Prevalence
  • Risk Factors



Research group

  • Celiac Disease and Diabetes Unit
  • Diabetes - Cardiovascular Disease
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Immunovirology
  • Paediatric Endocrinology


  • ISSN: 0077-8923