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Carina Törn

Coordinator

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Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

Author

  • Hanna Skärstrand
  • Fariba Vaziri Sani
  • Ahmed Delli
  • Carina Törn
  • Helena Larsson
  • Sten Ivarsson
  • Daniel Agardh
  • Åke Lernmark

Summary, in English

Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine neuropeptide Y (NPY-LA) and autoantibodies to proline neuropeptide Y (NPY-PA) on the diagnostic sensitivity of type 1 diabetes (T1D), (ii) the association of NPYA with major islet autoantibodies, and (iii) the association of NPYA with HLA-DQ genotypes in newly diagnosed T1D patients.

Department/s

  • Celiac Disease and Diabetes Unit
  • Paediatric Endocrinology
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2015

Language

English

Pages

621-628

Publication/Series

Pediatric Diabetes

Volume

16

Issue

8

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Endocrinology and Diabetes
  • Pediatrics

Status

Published

Research group

  • Diabetes and Celiac Unit
  • Paediatric Endocrinology

ISBN/ISSN/Other

  • ISSN: 1399-543X