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Carin Andrén Aronsson

Head of unit

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Associations of breastfeeding with childhood autoimmunity, allergies, and overweight : The Environmental Determinants of Diabetes in the Young (TEDDY) study

Author

  • Sandra Hummel
  • Andreas Weiß
  • Ezio Bonifacio
  • Daniel Agardh
  • Beena Akolkar
  • Carin A Aronsson
  • William A Hagopian
  • Sibylle Koletzko
  • Jeffrey P Krischer
  • Åke Lernmark
  • Kristian Lynch
  • Jill M Norris
  • Marian J Rewers
  • Jin-Xiong She
  • Jorma Toppari
  • Ulla Uusitalo
  • Kendra Vehik
  • Suvi M Virtanen
  • Andreas Beyerlein
  • Anette-G Ziegler

Summary, in English

BACKGROUND: Breastfeeding has beneficial effects on numerous health outcomes.

OBJECTIVES: We investigated whether breastfeeding duration is associated with the development of early childhood autoimmunity, allergies, or obesity in a multinational prospective birth cohort.

METHODS: Infants with genetic susceptibility for type 1 diabetes (n = 8676) were followed for the development of autoantibodies to islet autoantigens or transglutaminase, allergies, and for anthropometric measurements to a median age of 8.3 y (IQR: 2.8-10.2 y). Information on breastfeeding was collected at 3 mo of age and prospectively thereafter. A propensity score for longer breastfeeding was calculated from the variables that were likely to influence any or exclusive breastfeeding. The risks of developing autoimmunity or allergy were assessed using Cox proportional hazards models, and the risk of obesity at 5.5 y of age was assessed using logistic regression with adjustment by the propensity score.

RESULTS: Breastfeeding duration was not associated with a lower risk of either islet or transglutaminase autoimmunity (any breastfeeding >6 mo, adjusted HR: 1.07; 95% CI: 0.96, 1.19; exclusive breastfeeding >3 mo, adjusted HR: 1.03; 95% CI: 0.92, 1.15). Exclusive breastfeeding >3 mo was associated with a decreased risk of seasonal allergic rhinitis (adjusted HR: 0.70; 95% CI: 0.53, 0.92; P < 0.01). Any breastfeeding >6 mo and exclusive breastfeeding >3 mo were associated with decreased risk of obesity (adjusted OR: 0.62; 95% CI: 0.47, 0.81; P < 0.001; and adjusted OR: 0.68; 95% CI: 0.47, 0.95; P < 0.05, respectively).

CONCLUSIONS: Longer breastfeeding was not associated with a lower risk of childhood (islet or transglutaminase) autoimmunity in genetically at-risk children but was associated with decreased risk of seasonal allergic rhinitis and obesity at 5.5 y of age.

Department/s

  • EpiHealth: Epidemiology for Health
  • Diabetes and Celiac Unit
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2021-04-08

Language

English

Pages

134-142

Publication/Series

The American journal of clinical nutrition

Volume

114

Issue

1

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISSN: 1938-3207