Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Carin Andrén Aronsson

Head of unit

Default user image.

The Environmental Determinants of Diabetes in the Young (TEDDY) Study

Author

  • Marian Rewers
  • Åke Lernmark
  • Daniel Agardh
  • Peter Almgren
  • Carin Andrén Aronsson
  • Maria Ask
  • Ulla-Marie Carlsson
  • Corrado Cilio
  • Jenny Bremer
  • Joanna Gerardsson
  • Barbro Gustavsson
  • Gertie Hansson
  • Ida Jönsson
  • Monica Hansen
  • Susanne Hyberg
  • Sten Ivarsson
  • Helena Larsson
  • Barbro Lernmark
  • Maria Markan
  • Marie Jessica Melin
  • Maria Månsson Martinez
  • Kobra Rahmati
  • Monica Sedig-Järvirova
  • Birgitta Sjöberg
  • Carina Törn
  • Anne Wallin
  • Ingrid Wigheden
  • Åsa Wimar

Other contributions

  • Steve Oberste

Summary, in English

The etiology of type 1 diabetes (T1D) remains unknown, but a growing body of evidence points to infectious agents and/or components of early childhood diet. The National Institutes of Health has established the TEDDY Study consortium of six clinical centers in the United States and Europe and a data coordinating center to identify environmental factors predisposing to, or protective against, islet autoimmunity and T1D. From 2004-2009, TEDDY will screen more than 360,000 newborns from both the general population and families already affected by T1D to identify an estimated 17,804 children with high-risk HLA-DR,DQ genotypes. Of those, 7,801 (788 first-degree relatives and 7,013 newborns with no family history of T1D) will be enrolled in prospective follow-up beginning before the age of 4.5 months. As of May 2008, TEDDY has screened more than 250,000 newborns and enrolled nearly 5,000 infants--approximately 70% of the final cohort. Participants are seen every 3 months up to 4 years of age, with subsequent visits every 6 months until the subject is 15 years of age. Blood samples are collected at each visit for detection of candidate infectious agents and nutritional biomarkers; monthly stool samples are collected for infectious agents. These samples are saved in a central repository. Primary endpoints include (1) appearance of one or more islet autoantibodies (to insulin, GAD65 or IA-2) confirmed at two consecutive visits; (2) development of T1D. By age 15, an estimated 800 children will develop islet autoimmunity and 400 will progress to T1D; 67 and 27 children have already reached these endpoints.

Department/s

  • Diabetes and Celiac Unit
  • Diabetes - Cardiovascular Disease
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Immunovirology
  • Paediatric Endocrinology

Publishing year

2008

Language

English

Pages

1-13

Publication/Series

Annals of the New York Academy of Sciences

Volume

1150

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Endocrinology and Diabetes

Keywords

  • Adolescent
  • Autoantibodies/analysis
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1/epidemiology
  • Environment
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Immunologic Techniques/standards
  • Infant
  • Mass Screening
  • Prevalence
  • Risk Factors

Status

Published

Research group

  • Diabetes and Celiac Unit
  • Diabetes - Cardiovascular Disease
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Immunovirology
  • Paediatric Endocrinology

ISBN/ISSN/Other

  • ISSN: 0077-8923