
Carin Andrén Aronsson
Head of unit

The Environmental Determinants of Diabetes in the Young (TEDDY) Study
Author
Other contributions
- Steve Oberste
Summary, in English
The etiology of type 1 diabetes (T1D) remains unknown, but a growing body of evidence points to infectious agents and/or components of early childhood diet. The National Institutes of Health has established the TEDDY Study consortium of six clinical centers in the United States and Europe and a data coordinating center to identify environmental factors predisposing to, or protective against, islet autoimmunity and T1D. From 2004-2009, TEDDY will screen more than 360,000 newborns from both the general population and families already affected by T1D to identify an estimated 17,804 children with high-risk HLA-DR,DQ genotypes. Of those, 7,801 (788 first-degree relatives and 7,013 newborns with no family history of T1D) will be enrolled in prospective follow-up beginning before the age of 4.5 months. As of May 2008, TEDDY has screened more than 250,000 newborns and enrolled nearly 5,000 infants--approximately 70% of the final cohort. Participants are seen every 3 months up to 4 years of age, with subsequent visits every 6 months until the subject is 15 years of age. Blood samples are collected at each visit for detection of candidate infectious agents and nutritional biomarkers; monthly stool samples are collected for infectious agents. These samples are saved in a central repository. Primary endpoints include (1) appearance of one or more islet autoantibodies (to insulin, GAD65 or IA-2) confirmed at two consecutive visits; (2) development of T1D. By age 15, an estimated 800 children will develop islet autoimmunity and 400 will progress to T1D; 67 and 27 children have already reached these endpoints.
Department/s
- Celiac Disease and Diabetes Unit
- Diabetes - Cardiovascular Disease
- Genomics, Diabetes and Endocrinology
- Diabetes - Immunovirology
- Paediatric Endocrinology
Publishing year
2008
Language
English
Pages
1-13
Publication/Series
Annals of the New York Academy of Sciences
Volume
1150
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Endocrinology and Diabetes
Keywords
- Adolescent
- Autoantibodies/analysis
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1/epidemiology
- Environment
- Follow-Up Studies
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Immunologic Techniques/standards
- Infant
- Mass Screening
- Prevalence
- Risk Factors
Status
Published
Research group
- Celiac Disease and Diabetes Unit
- Diabetes - Cardiovascular Disease
- Genomics, Diabetes and Endocrinology
- Diabetes - Immunovirology
- Paediatric Endocrinology
ISBN/ISSN/Other
- ISSN: 0077-8923