
Carin Andrén Aronsson
Head of unit

Early probiotic supplementation and the risk of celiac disease in children at genetic risk
Author
Summary, in English
Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.
Department/s
- Celiac Disease and Diabetes Unit
- EXODIAB: Excellence of Diabetes Research in Sweden
Publishing year
2019-08-01
Language
English
Publication/Series
Nutrients
Volume
11
Issue
8
Document type
Journal article
Publisher
MDPI AG
Topic
- Pediatrics
- Nutrition and Dietetics
Keywords
- Celiac disease
- Celiac disease autoimmunity
- Dietary supplements
- Infant formula
- Probiotics
Status
Published
Research group
- Celiac Disease and Diabetes Unit
ISBN/ISSN/Other
- ISSN: 2072-6643