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24

Apr

CRC seminar - Professor Scott A. Summers

24 April 2026 11:00 to 12:00 |
Photograph of Scott A. Summers.
Scott A. Summers of University of Utah will give a talk on a novel ceramide-lowering therapy to treat cardiometabolic disease. Photograph: University of Utah

The CRC seminars bring up current medical research by researchers at Clinical Research Centre (CRC), Lund University and invited guests.

Speaker

Professor Scott A. Summers, University of Utah, Salt Lake City, Utah, US

Title

A novel ceramide-lowering therapy to treat cardiometabolic disease

Host

Professor Philipp Kaldis

Abstract

Overnutrition, inflammation, and genetic aberrations promote the accumulation of sphingolipids such as ceramides, which alter metabolic programs and induce apoptosis in a wide range of cell types. In humans, serum ceramides are biomarkers of diabetes and major adverse cardiac events, and clinics have started measuring circulating ceramides as markers of disease risk. In rodents, inhibiting ceramide biosynthesis ameliorates diabetes, steatohepatitis, kidney injury, and heart failure.  The author will discuss the evolution of this pathway as a signal of lipid excess and the therapeutic potential of a new approach to inactivate ceramides and combat cardiometabolic pathologies.

 

 

About the event

Location:

Seminar room 92-09-014, CRC, Jan Waldenströms gata 35

Contact:

ulrika [dot] blom-nilsson [at] med [dot] lu [dot] se