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Ashfaq Ali

Bioinformatician

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Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

Author

  • Min Kim
  • Ashfaq Ali
  • Cristina Legido-Quigley

Summary, in English

Introduction: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. Methods: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis. Results: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory. Discussion: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures. © 2019

Publishing year

2019-06

Language

English

Pages

817-827

Publication/Series

Alzheimer's and Dementia

Volume

15

Issue

6

Document type

Journal article

Publisher

Wiley

Topic

  • Neurosciences

Keywords

  • Alzheimer's disease
  • Amyloid
  • Biomarkers
  • Brain volume measurements
  • Cognitive function measurements
  • CSF
  • Dementia
  • EMIF-AD
  • Metabolomics
  • Tau
  • amide
  • amino acid
  • amyloid beta protein
  • aspartic acid
  • biological marker
  • cholinesterase inhibitor
  • fatty acid
  • glutamic acid
  • oleamide
  • tau protein
  • aged
  • Alzheimer disease
  • Article
  • brain function
  • brain size
  • cognition
  • cohort analysis
  • controlled study
  • dementia
  • disease association
  • female
  • hippocampus
  • human
  • logistic regression analysis
  • major clinical study
  • male
  • memory
  • metabolomics
  • mild cognitive impairment
  • Mini Mental State Examination
  • neuropsychological test
  • nuclear magnetic resonance imaging
  • plasma
  • predictive value
  • priority journal
  • protein cerebrospinal fluid level

Status

Published

ISBN/ISSN/Other

  • ISSN: 1552-5279