Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Åsalinda Lethagen

Physician

Default user image.

Clinical, Genetic and Metabolic Characterisation of LADA (Latent Autoimmune Diabetes in Adults)

Author

  • ÅsaLinda Lethagen

Summary, in English

Latent autoimmune diabetes in adults (LADA) comprises about 10% of patients initially diagnosed with type 2 diabetes but who are positive for pancreatic islet antibodies, especially to glutamic acid decarboxylase (GADabs). The present studies focused on clinical, genetic and metabolic characterisation of patients with LADA. In LADA, the frequency of the type 1 diabetes susceptibility genotype HLA-DQB1*0201/*0302 and genotypes including the 0302 allele was higher than in type 2 diabetes but lower than in type 1 diabetes. No difference was seen between LADA and type 2 diabetic or control subjects regarding the frequency of the insulin gene alleles associated with the risk of type 1 diabetes, whereas the frequency of these alleles was high in type 1 diabetic patients. In the LADA subjects, beta-cell function was significantly impaired at diagnosis compared with type 2 diabetic patients, but was markedly better preserved compared with age-matched adult type 1 diabetic patients. GADab positivity was linked with decreased insulin secretion in non-diabetic subjects, suggesting that GADabs are markers of beta-cell autoimmunity, although this does not always lead to overt diabetes. Features of the metabolic syndrome in LADA were fewer than in type 2 diabetes but more common than in type 1 diabetes. The results show that although LADA shares characteristics with both type 1 and type 2 diabetes it can be clinically, genetically, and metabolically distinguished from both types. The distinction is of clinical importance for identifying LADA and to achieve proper care of these patients.

Department/s

  • Genomics, Diabetes and Endocrinology

Publishing year

2002

Language

English

Document type

Dissertation

Publisher

ÅsaLinda Lethagen Wallenberg Laboratory ing 46, Malmö University Hospital, 20502 Malmö, Sweden,

Topic

  • Endocrinology and Diabetes

Keywords

  • metabolic syndrome
  • insulin sensitivity
  • insulin secretion
  • GADabs
  • glutamic acid decarboxylase autoantibodies
  • Type 2 diabetes
  • LADA
  • Type 1 diabetes
  • IDDM1
  • IDDM2
  • Endocrinology
  • secreting systems
  • diabetology
  • Endokrinologi
  • sekretion
  • diabetologi

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

Supervisor

  • [unknown] [unknown]

ISBN/ISSN/Other

  • ISBN: 91-628-5124-1

Defence date

4 April 2002

Defence time

09:15

Defence place

The Medical Research Centre (Jubileumsaulan), Malmö University Hospital

Opponent

  • Paul Zimmet (Professor)