
Annelie Shami
Assistant researcher

Plaque vulnerability in atherosclerosis: Driven by interplay between co-stimulatory signalling and extracellular matrix?
The integriity of the extracellular matrix (ECM) - the dynamic structures making up the microenvironment around cells - is of crucial impostance for the development and stability of atherosclerotic plaques. Key players in modulating inflammatory reactions in such lesions are the co-stimulatory molecules that direct the actions of immune cells. I believe that the co-stimulatory molecules are a key link between inflammation and the ECM milieu, allowing interactions between immune cells and plaque ECM to be the driving force behind atherosclerotic plaque destabilization. The aim of my research is to define how atherosclerotic plaque progression is driven via co-stimulatory molecules´ effeccts on ECMintegrity, and my ultimate goal is to identify new drug targets and strategies to promote plaque stability.
To reach my goal I am analysing both human and mouse plaques to identify
- co-stimulatory molecules expression patterns in plaques
- how interplay between co-stimulatory molecules and ECM components in plaques affects plaque vulnerability, and
- the specific molelcular mechanisms that link co-stimulatory signalling and ECM turnover.
Publications
Displaying of publications. Sorted by year, then title.
Diverse ultrastructural landscape of atherosclerotic endothelium
Ewelina Kluza, Thijs J. Beldman, Annelie Shami, Edwin R. Scholl, Tsveta S. Malinova, et al.
(2021) Atherosclerosis, 339 p.35-45
Journal articleExtracellular matrix: paving the way to the newest trends in atherosclerosis
Chrysostomi Gialeli, Annelie Shami, Isabel Gonçalves
(2021) Current Opinion in Lipidology, 32 p.277-285
Journal articleSoluble CD40 levels in plasma are associated with cardiovascular disease and in carotid plaques with a vulnerable phenotype
Annelie Shami, Andreas Edsfeldt, Eva Bengtsson, Jan Nilsson, Angela C. Shore, et al.
(2021) Journal of Stroke, 23 p.367-376
Journal articleGlucocorticoid induced TNF receptor family-related protein (GITR) – A novel driver of atherosclerosis
Laura A. Bosmans, Annelie Shami, Dorothee Atzler, Christian Weber, Isabel Gonçalves, et al.
(2021) Vascular Pharmacology, 139
Journal article reviewCell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, et al.
(2021) Nature Communications, 12
Journal articleGlucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans
Annelie Shami, Dorothee Atzler, Laura A. Bosmans, Holger Winkels, Svenja Meiler, et al.
(2020) European Heart Journal, 41 p.2938-2948
Journal articleDystrophin deficiency reduces atherosclerotic plaque development in ApoE-null mice.
Annelie Shami, Anki Knutsson, Pontus Dunér, Uwe Rauch, Eva Bengtsson, et al.
(2015) Scientific Reports, 5
Journal articleExpression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.
Annelie Shami, Christoffer Tengryd, Giuseppe Asciutto, Eva Bengtsson, Jan Nilsson, et al.
(2015) Atherosclerosis, 241 p.701-708
Journal articleFibromodulin and Dystrophin in Atherosclerosis: Novel roles for extracellular matrix in plaque development
Annelie Shami
(2014) Lund University Faculty of Medicine Doctoral Dissertation Series, 2014:10
DissertationCollagen and related extracellular matrix proteins in atherosclerotic plaque development.
Annelie Shami, Isabel Goncalves, Anna Hultgårdh
(2014) Current Opinion in Lipidology, 25 p.394-399
Journal article reviewFibromodulin Deficiency Reduces Low-Density Lipoprotein Accumulation in Atherosclerotic Plaques in Apolipoprotein E-Null Mice.
Annelie Shami, Renata Gustafsson, Sebastian Kalamajski, Rob Krams, Dolf Segers, et al.
(2012) Arteriosclerosis, Thrombosis and Vascular Biology
Journal articleIncreased Neointimal Thickening in Dystrophin-Deficient mdx Mice.
Uwe Rauch, Annelie Shami, Feng Zhang, Virginie Carmignac, Madeleine Durbeej-Hjalt, et al.
(2012) PLoS ONE, 7
Journal article