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ludc web

Anna Wendt

Assistant researcher

ludc web

Islet microRNAs in health and type-2 diabetes

Author

  • Anna Wendt
  • Jonathan LS Esguerra
  • Lena Eliasson

Summary, in English

Failure of the β-cell to secrete enough insulin is a major contributing factor in the pathogenesis of type-2 diabetes (T2D). MicroRNAs provide an extra layer in the regulation of protein expression, and are thus involved in β-cell compensation during development of the disease. In this review, we discuss how microRNAs can regulate their target protein expression and phenotypic output, present the status of nutritional regulation of microRNA expression, and summarize work on microRNA expression in human islets. In conclusion, current data lend support to microRNAs being essential regulators of insulin secretion. Future work will describe microRNAs in α-cell function, details of the microRNA–mRNA network, and possibilities to use microRNAs as biomarkers and in therapeutic treatment of T2D and complications.

Department/s

  • Diabetes - Islet Cell Exocytosis
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2018-12-01

Language

English

Pages

46-52

Publication/Series

Current Opinion in Pharmacology

Volume

43

Document type

Journal article review

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes - Islet Cell Exocytosis

ISBN/ISSN/Other

  • ISSN: 1471-4892