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ludc web

Anna Wendt

Assistant researcher

ludc web

Selectively Bred Diabetes Models : GK Rats, NSY Mice, and ON Mice

Author

  • Mototsugu Nagao
  • Jonathan Lou S Esguerra
  • Anna Wendt
  • Akira Asai
  • Hitoshi Sugihara
  • Shinichi Oikawa
  • Lena Eliasson

Editor

  • A King

Summary, in English

The polygenic background of selectively bred diabetes models mimics the etiology of type 2 diabetes. So far, three different rodent models (Goto-Kakizaki rats, Nagoya-Shibata-Yasuda mice, and Oikawa-Nagao mice) have been established in the diabetes research field by continuous selective breeding for glucose tolerance from outbred rodent stocks. The origin of hyperglycemia in these rodents is mainly insulin secretion deficiency from the pancreatic β-cells and mild insulin resistance in insulin target organs. In this chapter, we summarize backgrounds and phenotypes of these rodent models to highlight their importance in diabetes research. Then, we introduce experimental methodologies to evaluate β-cell exocytosis as a putative common defect observed in these rodent models.

Department/s

  • Diabetes - Islet Cell Exocytosis
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2020-03-17

Language

English

Pages

25-54

Publication/Series

Methods in molecular biology (Clifton, N.J.)

Volume

2128

Document type

Book chapter

Publisher

Humana Press

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes - Islet Cell Exocytosis

ISBN/ISSN/Other

  • ISSN: 1940-6029
  • ISBN: 978-1-0716-0385-7
  • ISBN: 978-1-0716-0384-0