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ludc web

Anna Wendt

Assistant researcher

ludc web

Lessons from basic pancreatic beta cell research in type-2 diabetes and vascular complications

Author

  • Lena Eliasson
  • Jonathan Lou S. Esguerra
  • Anna Wendt

Summary, in English

The changes in life-style with increased access of food and reduced physical activity have resulted in the global epidemic of obesity. Consequently, individuals with type 2 diabetes and cardiovascular disease have also escalated. A central organ in the development of diabetes is the pancreas, and more specifically the pancreatic beta cells within the islets of Langerhans. Beta cells have been assigned the important task of secreting insulin when blood glucose is increased to lower the glucose level. An early sign of diabetes pathogenesis is lack of first phase insulin response and reduced second phase secretion. In this review, which is based on the foreign investigator award lecture given at the JSDC meeting in Sendai in October 2016, we discuss a possible cellular explanation for the reduced first phase insulin response and how this can be influenced by lipids. Moreover, since patients with cardiovascular disease and high levels of cholesterol are often treated with statins, we summarize recent data regarding effects on statins on glucose homeostasis and insulin secretion. Finally, we suggest microRNAs (miRNAs) as central players in the adjustment of beta cell function during the development of diabetes. We specifically discuss miRNAs regarding their involvement in insulin secretion regulation, differential expression in type 2 diabetes, and potential as biomarkers for prediction of diabetes and cardiovascular complications.

Department/s

  • Department of Clinical Sciences, Malmö
  • Diabetes - Islet Cell Exocytosis
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2017

Language

English

Pages

139-152

Publication/Series

Diabetology International

Volume

8

Issue

2

Document type

Journal article review

Publisher

Springer

Topic

  • Endocrinology and Diabetes
  • Cell and Molecular Biology

Keywords

  • MicroRNA
  • Type 2 diabetes mellitus
  • Pancreatic beta cell
  • Insulin secretion
  • Obesity
  • Statins

Status

Published

Research group

  • Diabetes - Islet Cell Exocytosis

ISBN/ISSN/Other

  • ISSN: 2190-1686