Anna Wendt
Assistant researcher
Anna Wendt is an assistant professor in Cellular Physiology at Lund University since 2017 and she is part of the Lund University Diabetes Centre (LUDC). Anna has a master degree in Biology (1998) and PhD in Physiology (2004), both from Lund University. Annas research is focused on how intrinsic and extrinsic pathways regulate hormone-secretion from the islets of Langerhans. Her main focus has been on the regulation of insulin secretion using electrophysiology and molecular biology to deduce how insulin secretion is regulated in health and disease. Lately she has taken an interest in the role of glucagon secretion in type-2 diabetes and how alpha cell identity and function is regulated by microRNAs.
Publications
Displaying of publications. Sorted by year, then title.
Human pancreatic islet miRNA-mRNA networks of altered miRNAs due to glycemic status
Alexandros Karagiannopoulos, Jonathan LS Esguerra, Morten Pedersen, Anna Wendt, Rashmi Prasad, et al.
(2022) iScience, 25
Journal articlePancreatic alpha cells and glucagon secretion : Novel functions and targets in glucose homeostasis
Anna Wendt, Lena Eliasson
(2022) Current Opinion in Pharmacology, 63
Journal article reviewHuman Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion
Jones Ofori, Alexandros Karagiannopoulos, Mototsugu Nagao, Efraim Westholm, Shaima Ramadan, et al.
(2022) Diabetes, 71 p.275-284
Journal articleThe highly expressed calcium-insensitive synaptotagmin-11 and synaptotagmin-13 modulate insulin secretion
Jones K Ofori, Alexandros Karagiannopoulos, Mohammad Barghouth, Mototsugu Nagao, Markus E Andersson, et al.
(2022) Acta Physiologica , p.13857-13857
Journal articleIslet Function in the Pathogenesis of Cystic Fibrosis-Related Diabetes Mellitus
Efraim Westholm, Anna Wendt, Lena Eliasson
(2021) Clinical Medicine Insights: Endocrinology and Diabetes, 14 p.1-7
Journal article reviewPancreatic α-cells – The unsung heroes in islet function
Anna Wendt, Lena Eliasson
(2020) Seminars in Cell and Developmental Biology, 103 p.41-50
Journal article reviewPotential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells
Mototsugu Nagao, Jonathan L S Esguerra, Akira Asai, Jones K Ofori, Anna Edlund, et al.
(2020) Diabetes, 69 p.1193-1205
Journal articleSelectively Bred Diabetes Models : GK Rats, NSY Mice, and ON Mice
Mototsugu Nagao, Jonathan Lou S Esguerra, Anna Wendt, Akira Asai, Hitoshi Sugihara, et al.
(2020) Methods in molecular biology (Clifton, N.J.), 2128 p.25-54
Book chapterDefective exocytosis and processing of insulin in a cystic fibrosis mouse model
Anna Edlund, Mohammad Barghouth, Michael Huhn, Mia Abels, Jonathan Esguerra, et al.
(2019) Journal of Endocrinology, 241 p.45-57
Journal articleIslet microRNAs in health and type-2 diabetes
Anna Wendt, Jonathan LS Esguerra, Lena Eliasson
(2018) Current Opinion in Pharmacology, 43 p.46-52
Journal article reviewMicroRNAs in islet hormone secretion
Jonathan L.S. Esguerra, Mototsugu Nagao, Jones K. Ofori, Anna Wendt, Lena Eliasson
(2018) Diabetes, Obesity and Metabolism, 20 p.11-19
Journal article reviewMiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles
Vishal A. Salunkhe, Jones K. Ofori, Nikhil R. Gandasi, Sofia A. Salö, Sofia Hansson, et al.
(2017) Physiological Reports, 5
Journal articleCD36 is increased in human islets from obese type 2 diabetes donors, and affects beta cell function by the modulation of exocytotic proteins and insulin content
M. Nagao, J. L. S. Esguerra, J. K. Ofori, A. Wendt, A. Asai, et al.
(2017) Diabetologia, 60 p.185-186
Conference paper: abstractSox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
Annika Axelsson, T Mahdi, H A Nenonen, Tania Singh, S Hänzelmann, et al.
(2017) Nature Communications, 8 p.15652-15652
Journal articleNeuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival
Jon Agraves Juan-Mateu, Tatiana H Rech, Olatz Villate, Esther Lizarraga-Mollinedo, Anna Wendt, et al.
(2017) Journal of Biological Chemistry, 292 p.3466-3480
Journal articleOsteopontin affects insulin vesicle localization and Ca2+ homeostasis in pancreatic beta cells from female mice
Anna Wendt, Ines Mollet, Anki Knutsson, Victor S. Bolmgren, Anna Hultgårdh, et al.
(2017) PLoS ONE, 12
Journal articleLessons from basic pancreatic beta cell research in type-2 diabetes and vascular complications
Lena Eliasson, Jonathan Lou S. Esguerra, Anna Wendt
(2017) Diabetology International, 8 p.139-152
Journal article reviewIntegrator of stress responses calmodulin binding transcription activator 1 (Camta1) Regulates miR-212/miR-132 Expression and insulin secretion
Inês Guerra Uerra Mollet, Helena Anna Malm, Anna Wendt, Marju Orho-Melander, Lena Eliasson
(2016) Journal of Biological Chemistry, 291 p.18440-18452
Journal articleDual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion
Vishal A. Salunkhe, Ines Mollet, Jones K. Ofori, Helena A. Malm, Jonathan L S Esguerra, et al.
(2016) EBioMedicine, 10 p.185-194
Journal articleRosuvastatin treatment affects both basal and glucose-induced insulin secretion in INS-1 832/13 cells
Vishal A. Salunkhe, Olof Elvstam, Lena Eliasson, Anna Wendt
(2016) PLoS ONE, 11
Journal articleMiR-335 regulates exocytotic proteins and affects glucose-stimulated insulin secretion through decreased Ca2+-dependent exocytosis in beta cells
V.A. Salunkhe, J. Ofori, N.R. Gandasi, S.A. Salö, A. Wendt, et al.
(2015) Diabetologia, 58 p.128-128
Conference paper: abstractModulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells.
Vishal Ashok Salunkhe, Jonathan Esguerra, Jones Ofori, Ines Mollet, Matthias Braun, et al.
(2015) Acta Physiologica, 213 p.882-892
Journal articleBone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents
Gitte L. Christensen, Maria L. B. Jacobsen, Anna Wendt, Ines Mollet, Josefine Friberg, et al.
(2015) Diabetologia, 58 p.1282-1290
Journal articleExposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice
Johanna Bodin, Anette Kocbach Bølling, Anna Wendt, Lena Eliasson, Rune Becher, et al.
(2015) Toxicology Reports, 2 p.99-110
Journal articleCFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.
Anna Edlund, Jonathan Esguerra, Anna Wendt, Malin Flodström-Tullberg, Lena Eliasson
(2014) BMC Medicine, 12
Journal articleRegulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.
Jonathan Esguerra, Ines Mollet, Vishal Ashok Salunkhe, Anna Wendt, Lena Eliasson
(2014) Genes, 5 p.1018-1031
Journal article reviewProgesterone metabolite influence feeding behaviour.
Anna Wendt, Lena Eliasson
(2013) Acta Physiologica, 208 p.296-297
Journal article (comment)Synapsins I and II Are Not Required for Insulin Secretion from Mouse Pancreatic beta-cells
Anna Wendt, Dina Speidel, Anders Danielsson, Jonathan L. S. Esguerra, Inger Lise Bogen, et al.
(2012) Endocrinology, 153 p.2112-2119
Journal articleBeta-cell specific deletion of dicer1 leads to defective insulin secretion and diabetes mellitus.
Martins Kalis, Caroline Bolmeson, Jonathan Esguerra, Shashank Gupta, Anna Edlund, et al.
(2011) PLoS ONE, 6
Journal articlePleiotropic Effects of GIP on Islet Function Involve Osteopontin
Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, et al.
(2011) Diabetes, 60 p.2424-2433
Journal articleDeletion of the G protein-coupled Receptor GPR30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-stimulated Insulin Release in Female Mice.
Ulrika Mårtensson, S Albert Salehi, Sara Windahl, Maria Gomez, Karl Swärd, et al.
(2009) Endocrinology, 150 p.687-698
Journal articleCaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells.
Marloes Dekker Nitert, Cecilia Nagorny, Anna Wendt, Lena Eliasson, Hindrik Mulder
(2008) Journal of Molecular Endocrinology, 41 p.1-11
Journal articleCorelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells
Matthias Braun, Anna Wendt, Jovita Karanauskaite, Juris Galvanovskis, Anne Clark, et al.
(2007) Journal of General Physiology, 129 p.221-231
Journal articleIntra-islet insulin suppresses glucagon release via GABA-GABA(A) receptor system
E Xu, M Kumar, Y Zhang, W Ju, T Obata, et al.
(2006) Cell Metabolism, 3 p.47-58
Journal articleRegulated Exocytosis of GABA-containing Synaptic-like Microvesicles in Pancreatic {beta}-cells.
Matthias Braun, Anna Wendt, Bryndis Birnir, Jonas Broman, Lena Eliasson, et al.
(2004) Journal of General Physiology, 123 p.191-204
Journal articleGABAB-receptor activation inhibits exocytosis in rat pancreatic {beta}-cells by G-protein-dependent activation of calcineurin.
Matthias Braun, Anna Wendt, Karsten Buschard, Albert Salehi, Sabine Sewing, et al.
(2004) Journal of Physiology, 559 p.397-409
Journal articleGlucose Inhibition of Glucagon Secretion From Rat alpha-Cells Is Mediated by GABA Released From Neighboring beta-Cells.
Anna Wendt, Bryndis Birnir, Karsten Buschard, Jesper Gromada, S Albert Salehi, et al.
(2004) Diabetes, 53 p.1038-1045
Journal articleImpaired insulin secretion and glucose tolerance in beta cell-selective Ca(V)1.2 Ca(2+) channel null mice.
Verena Schulla, Erik Renström, Robert Feil, Susanne Feil, Isobel Franklin, et al.
(2003) EMBO Journal, 22 p.3844-3854
Journal articleDelay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells.
Sebastian Barg, Charlotta Olofsson, Jenny Schriever-Abeln, Anna Wendt, Samuel Gebre-Medhin, et al.
(2002) Neuron, 33 p.287-299
Journal articleImportance of the 3' untranslated region of ornithine decarboxylase mRNA in the translational regulation of the enzyme
E Lövkvist Wallström, K Takao, A Wendt, C Vargiu, H Yin, et al.
(2001) The Biochemical journal, 356 p.34-627
Journal article