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Anna Dutius Andersson

Anna-Maria Dutius Andersson

Biomedical analyst

Anna Dutius Andersson

Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.

Author

  • Anna Zetterqvist
  • Lisa Berglund
  • Fabiana Blanco
  • Eliana Garcia Vaz
  • Maria Wigren
  • Pontus Dunér
  • Anna-Maria Dutius Andersson
  • Fong To
  • Peter Spégel
  • Jan Nilsson
  • Eva Bengtsson
  • Maria Gomez

Summary, in English

Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Diabetic Complications
  • Diabetes - Molecular Metabolism
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2013

Language

English

Publication/Series

PLoS ONE

Volume

8

Issue

6

Document type

Journal article

Publisher

Public Library of Science

Topic

  • Cardiac and Cardiovascular Systems
  • Clinical Medicine
  • Endocrinology and Diabetes

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Diabetic Complications
  • Diabetes - Molecular Metabolism

ISBN/ISSN/Other

  • ISSN: 1932-6203