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Anna-Lena Nilsson

Research student

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Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes

Author

  • Annika Lundstig
  • Sharia L McDonald
  • Marlena Maziarz
  • William C Weldon
  • Fariba Vaziri-Sani
  • Åke Lernmark
  • Anna-Lena Nilsson

Summary, in English

Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (n=67) and school children controls (n=292) from Jämtland county in Sweden. NLVA were found in 41 of 67 (61 %) patients compared to 127 of 292 (44 %) controls (P=0.009). In the type 1 diabetes patients, NLVA titres were associated with autoantibodies to glutamic acid decarboxylase (GADA) (P=0.023), but not to autoantibodies against insulin (IAA) or islet antigen-2 (IA-2A). The NLVA assay should prove useful for further investigations to determine levels of LV antibodies in patients and future studies to determine a possible role of LV in autoimmune type 1 diabetes.

Department/s

  • Diabetes and Celiac Unit
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Diabetic Complications
  • Paediatrics (Lund)

Publishing year

2021

Language

English

Publication/Series

The Journal of general virology

Volume

102

Issue

5

Document type

Journal article

Publisher

Microbiology Society

Topic

  • Infectious Medicine
  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes and Celiac Unit
  • Diabetic Complications

ISBN/ISSN/Other

  • ISSN: 1465-2099