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Anja Schmidt-Christensen

Assistant researcher

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The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosis

Author

  • Nina Fransén Pettersson
  • Adnan Deronic
  • Julia Nilsson
  • Tine Hannibal
  • Lisbeth Hansen
  • Anja Schmidt-Christensen
  • Fredrik Ivars
  • Dan Holmberg

Summary, in English

Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, even when the treatment was initiated after onset of disease. The reduced disease phenotype was associated with a systemic decrease in the number and reduced activation of disease-promoting transgenic natural killer T (NKT)-II cells and their type 2-cytokine expression profile. Paquinimod treatment also led to a reduction of CD115+ Ly6Chi monocytes and CD11b+ F4/80+ CD206+ macrophages.

Department/s

  • Autoimmunity
  • Stem Cell Center
  • Immunology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Neurosurgery

Publishing year

2018-09-05

Language

English

Publication/Series

PLoS ONE

Volume

13

Issue

9

Document type

Journal article

Publisher

Public Library of Science

Topic

  • Immunology in the medical area

Status

Published

Project

  • chronic Inflammation and fibrosis

Research group

  • Autoimmunity
  • Immunology

ISBN/ISSN/Other

  • ISSN: 1932-6203