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High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes

  • Jannet Svensson
  • Stefanie Eising
  • Henrik Bindesbol Mortensen
  • Michael Christiansen
  • Inga Laursen
  • Åke Lernmark
  • Anita Ramelius
  • Lars Bjarke Simonsen
  • Bendix Carstensen
  • Flemming Pociot
  • Jesper Johannesen
Publishing year: 2012
Language: English
Pages: 17-25
Publication/Series: Human Immunology
Volume: 73
Issue: 1
Document type: Journal article
Publisher: Elsevier

Abstract english

The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence in relation to Ig levels. Our aim was to describe Ig in children newly diagnosed with diabetes and in their healthy siblings. Children with T1D expressed significantly lower IgG (p < 0.01) and higher IgA levels (p = 0.045), whereas no differences in IgE or IgM (p > 0.5) levels were found. Age-specific levels were unchanged over a 9-year period. In patients and siblings IgG. IgA and IgE increased by age (p < 0.001); which was in contrast to IgM (p > 0.05). The continued increase in IgG levels by age indicates that adult levels are reached later than in previously studied cohorts, thereby indicating a slower maturation of the immune system. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.


  • Immunology in the medical area
  • Type 1 diabetes
  • Immunoglobulin
  • Incidence
  • Hygiene


  • Diabetes and Celiac Unit
  • ISSN: 0198-8859
E-mail: anita [dot] ramelius [at] med [dot] lu [dot] se

Biomedical analyst

Diabetes and Celiac Unit

+46 40 39 19 06


Jan Waldenströms gata 35, Malmö


Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00