Effects of palatable diets on appetite regulation, appetite peptides and neurogenesis.
Summary, in English
The removal of the stomach (gastrectomy) in mice resulted in an 80% reduction in circulating ghrelin (hypoghrelinemia), in decreased amount of adipose tissue and decreased thermogenesis and ghrelin, when given daily over a period of eight weeks, normalised the amount of adipose tissue and thermogenesis in gastrectomised mice.
A high fat diet was offered to rats in order to study the effect of such a diet on hippocampal neurogenesis. The high fat diet was found to impair neurogenesis in male rats, as indicated by a 40% reduction in newborn neurons. This effect was not observed in female rats. The high fat diet was also found to stimulate corticosterone in male rats (but not female rats), suggesting corticosterone to be responsible for the impairment in hippocampal neurogenesis.
- Basic Medicine
- Appetite regulation
- secreting systems
- Appetite Regulation
- Charlotte Erlanson-Albertsson
- ISBN: 91-85559-60-1
1 December 2006
Segerfalk Lecture Hall, BMC, Sölvegatan 19, Lund, Sweden
- John Blundell (Professor)