Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Andreas Lindqvist

Andreas Lindqvist

Research engineer

Andreas Lindqvist

Corticosteroids or Not for Postoperative Nausea : A Double-Blinded Randomized Study

Author

  • L. Nordin
  • A. Nordlund
  • Andreas Lindqvist
  • H. Gislason
  • J. L. Hedenbro

Summary, in English

Background: Postoperative nausea and vomiting (PONV) is common after general anaesthesia, and corticosteroids are used in many protocols for enhanced recovery after surgery (ERAS). However, surgical techniques are developing, and ERAS protocols need to be reevaluated from time to time. Patients and method: In this study, we compared the effects of oral vs. parenteral corticosteroid administration on postoperative nausea. Elective Roux-y-gastric bypass (RYGB) patients were randomly assigned to either 8 mg betamethasone orally (n = 50) or parentally (n = 25) or as controls (n = 25), in a double-blind design. PONV risk factors were noted. All patients had the same anaesthetic technique. Data were collected at baseline, on arrival to the recovery room (RR) and at five more time points during the first 24 h. Nausea and tiredness were patient assessed using visual analogue scales; rescue drug consumption was recorded. Results: Operation time was 30–40 min. Neither demographics nor risk factors for nausea differed between groups. Neither peak values for nor total amount of nausea differed between groups. The number of supplemental injections was the same for all groups. Comments: In a setting of modern laparoscopic RYGB, the value of betamethasone in preventing PONV seems to be limited. ERAS protocols may need re-evaluation.

Department/s

  • LUDC (Lund University Diabetes Centre)-lup-obsolete
  • Surgery (Lund)
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2016-05-23

Language

English

Pages

1517-1522

Publication/Series

Journal of Gastrointestinal Surgery

Volume

20

Issue

8

Document type

Journal article

Publisher

Springer

Topic

  • Gastroenterology and Hepatology

Keywords

  • Anaesthesia
  • Betamethasone
  • Corticosteroids
  • ERAS
  • Gastric bypass
  • Laparoscopy
  • Nausea
  • PONV
  • Tiredness

Status

Published

Research group

  • LUDC (Lund University Diabetes Centre)-lup-obsolete

ISBN/ISSN/Other

  • ISSN: 1091-255X