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Andreas Lindqvist

Andreas Lindqvist

Research engineer

Andreas Lindqvist

Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels

Author

  • Andreas Lindqvist
  • Mikael Ekelund
  • Stefan Pierzynowski
  • Leif Groop
  • Jan Hedenbro
  • Nils Wierup

Summary, in English

Gastric bypass surgery results in remission of type 2 diabetes in the majority of patients. The incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have been implicated in the observed remission. Most knowledge so far has been generated in obese subjects. To isolate the surgical effects of gastric bypass on metabolism and hormone responses from the confounding influence of obesity, T2D, or food intake, we performed gastric bypass in lean pigs, using sham-operated and pair-fed pigs as controls. Thus, pigs were subjected to Roux-en-Y gastric bypass (RYGB) or sham surgery and oral glucose tolerance tests (OGTT). RYGB pigs and sham pigs exhibited similar basal and 120-min glucose levels in response to the OGTT. However, RYGB pigs had approximately 1.6-fold higher 30-min glucose (p < 0.01). Early insulin release (EIR) was enhanced approximately 3.5-fold in the RYGB pigs (p < 0.01). Furthermore, GIP release, both acute and sustained release (p < 0.001 and p < 0.01, respectively), was increased approximately 2.5-fold and 1.4-fold, respectively, in RYGB pigs. Although total GLP-1 release increased approximately 2.1-fold after RYGB (p < 0.001), active GLP-1 was 33% lower (p < 0.01). Interestingly basal DPP4-activity was approximately 3.2-fold higher in RYGB pigs (p < 0.001). In conclusion, RYGB in lean pigs increases the response of GIP, total GLP-1, and insulin, but reduces levels of active GLP-1 in response to an oral glucose load. These data challenge the role of active GLP-1 as a contributor to remission from diabetes after RYGB.

Department/s

  • Neuroendocrine Cell Biology
  • Surgery (Lund)
  • Functional zoology
  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2017-04-01

Language

English

Pages

78-82

Publication/Series

Peptides

Volume

90

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology

Keywords

  • Bariatric surgery
  • Gastric Bypass
  • GIP
  • GLP-1
  • Insulin
  • Pig model

Status

Published

Research group

  • Neuroendocrine Cell Biology
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 0196-9781