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Andreas Lindqvist

Andreas Lindqvist

Research engineer

Andreas Lindqvist

Reduced neurogenesis in the rat hippocampus following high fructose consumption.

Author

  • Karin Van der Borght
  • Rickard Köhnke
  • Nathanael Göransson
  • Tomas Deierborg
  • Patrik Brundin
  • Charlotte Erlanson-Albertsson
  • Andreas Lindqvist

Summary, in English

In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of TNF-α. Therefore, we hypothesize that the reduction in hippocampal neurogenesis may be due to the increased apoptosis induced by TNF-α. Our results suggest that chronic ingestion of fructose is detrimental to the survival of newborn hippocampal neurones. The results presented in the present study add to the list of harmful effects associated with prolonged and excessive consumption of sugary beverages and soft drinks.

Department/s

  • Appetite Regulation
  • Department of Experimental Medical Science
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year

2011

Language

English

Pages

26-30

Publication/Series

Regulatory Peptides

Volume

167

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology

Status

Published

Research group

  • Appetite Regulation

ISBN/ISSN/Other

  • ISSN: 1873-1686