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Andreas Lindqvist

Andreas Lindqvist

Research engineer

Andreas Lindqvist

Liver blood dynamics after bariatric surgery : The effects of mixed-meal test and incretin infusions

Author

  • Henri Honka
  • Jukka Koffert
  • Saila Kauhanen
  • Nobuyuki Kudomi
  • Saija Hurme
  • Andrea Mari
  • Andreas Lindqvist
  • Nils Wierup
  • Riitta Parkkola
  • Leif Groop
  • Pirjo Nuutila

Summary, in English

Aims/hypothesis: The mechanisms for improved glycemic control after bariatric surgery in subjects with type 2 diabetes (T2D) are not fully known. We hypothesized that dynamic hepatic blood responses to a mixed-meal are changed after bariatric surgery in parallel with an improvement in glucose tolerance. Methods: A total of ten morbidly obese subjects with T2D were recruited to receive a mixed-meal and a glucose-dependent insulinotropic polypeptide (GIP) infusion before and early after (within a median of less than three months) bariatric surgery, and hepatic blood flow and volume (HBV) were measured repeatedly with combined positron emission tomography/MRI. Ten lean non-diabetic individuals served as controls. Results: Bariatric surgery leads to a significant decrease in weight, accompanied with an improved β-cell function and glucagon-like peptide 1 (GLP-1) secretion, and a reduction in liver volume. Blood flow in portal vein (PV) was increased by 1.65-fold (P = 0.026) in response to a mixed-meal in subjects after surgery, while HBV decreased in all groups (P < 0.001). When the effect of GIP infusion was tested separately, no change in hepatic arterial and PV flow was observed, but HBV decreased as seen during the mixed-meal test. Conclusions/interpretation: Early after bariatric surgery, PV flow response to a mixed-meal is augmented, improving digestion and nutrient absorption. GIP influences the post-prandial reduction in HBV thereby diverting blood to the extrahepatic sites.

Department/s

  • Neuroendocrine Cell Biology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Genomics, Diabetes and Endocrinology

Publishing year

2018

Language

English

Pages

888-896

Publication/Series

Endocrine Connections

Volume

7

Issue

7

Document type

Journal article

Publisher

BioScientifica

Topic

  • Endocrinology and Diabetes

Keywords

  • Bariatric surgery
  • Glucose-dependent insulinotropic polypeptide
  • Hepatic blood volume
  • Portal vein blood flow
  • Positron emission tomography

Status

Published

Research group

  • Neuroendocrine Cell Biology
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 2049-3614