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Andreas Lindqvist

Andreas Lindqvist

Research engineer

Andreas Lindqvist

Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents

Author

  • Emil Egecioglu
  • Bjorn Stenstrom
  • Scarlett B Pinnock
  • Loraine Y C Tung
  • Charlotta de la Cour
  • Andreas Lindqvist
  • Rolf Håkanson
  • Unni Syversen
  • Duan Chen
  • Suzanne L Dickson

Summary, in English

We investigated whether ghrelin depletion (by gastrectomy surgery) and/or treatment/replacement with the gastric hormone ghrelin alters the expression of key hypothalamic genes involved in energy balance, in a manner consistent with ghrelin's pro-obesity effects. At 2 weeks after surgery mice were treated with ghrelin (12 nmol/mouse/day, sc) or vehicle for 8 weeks. Gastrectomy had little effect on the expression of these genes, with the exception of NPY mRNA in the arcuate nucleus that was increased. Ghrelin treatment (to gastrectomized and sham mice) increased the mRNA expression of orexigenic peptides NPY and AgRP while decreasing mRNA expression of the anorexigenic peptide POMC. Two weeks gavage treatment with the ghrelin mimetic, MK-0677, to rats increased NPY and POMC mRNA in the arcuate nucleus and MCH mRNA in the lateral hypothalamus. Thus, while predicted pro-obesity ghrelin signalling pathways were activated by ghrelin and ghrelin mimetics, these were largely unaffected by gastrectomy.

Department/s

  • Department of Experimental Medical Science
  • Appetite Regulation
  • Drug Target Discovery

Publishing year

2008

Language

English

Pages

176-182

Publication/Series

Regulatory Peptides

Volume

146

Issue

1-3

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology

Status

Published

Research group

  • Appetite Regulation
  • Drug Target Discovery

ISBN/ISSN/Other

  • ISSN: 1873-1686