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Andreas Lindqvist

Andreas Lindqvist

Research engineer

Andreas Lindqvist

High-fat diet impairs hippocampal neurogenesis in male rats.

Author

  • Andreas Lindqvist
  • Paul Mohapel
  • B Bouter
  • Helena Frielingsdorf
  • D Pizzo
  • Patrik Brundin
  • Charlotte Erlanson-Albertsson

Summary, in English

High fat diets and obesity pose serious health problems, such as type II diabetes and cardiovascular disease. Impaired cognitive function is also associated with high fat intake. In this study, we show that just 4 weeks of feeding a diet rich in fat ad libitum decreased hippocampal neurogenesis in male, but not female, rats. There was no obesity, but male rats fed a diet rich in fat exhibited elevated serum corticosterone levels compared with those fed standard rat chow. These data indicate that high dietary fat intake can disrupt hippocampal neurogenesis, probably through an increase in serum corticosterone levels, and that males are more susceptible than females.

Department/s

  • Neuroendocrine Cell Biology
  • Wallenberg Neuroscience Centre, Lund
  • Department of Experimental Medical Science
  • Appetite Regulation

Publishing year

2006

Language

English

Pages

1385-1388

Publication/Series

European Journal of Neurology

Volume

13

Issue

12

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Neurology

Keywords

  • fat intake
  • obesity
  • memory
  • hippocampus
  • corticosterone

Status

Published

Research group

  • Neuroendocrine Cell Biology
  • Appetite Regulation

ISBN/ISSN/Other

  • ISSN: 1351-5101