Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Andreas Lindqvist

Andreas Lindqvist

Research engineer

Andreas Lindqvist

Decreased UCP2 mRNA expression in rat stomach following vagotomy: novel role for UCP2 as free radical scavenger in the stomach?

Author

  • Andreas Lindqvist
  • Jie Mei
  • Frank Sundler
  • Charlotte Erlanson-Albertsson

Summary, in English

Uncoupling protein 2 (UCP2) is a protein, located in the inner mitochondrial membrane, which dissipates the proton gradient of this membrane and uncouples respiration from oxidative phosphorylation. We found, by in situ hybridisation, UCP2 mRNA to be located in the proliferating zone of the mucous neck cells in the fundus part of the rat stomach. We also found that UCP2 expression in fundus was significantly decreased after seven days of vagotomy. Furthermore, we found manganese-containing superoxide dismutase (SOD2), in fundus, to be down-regulated in a way similar to UCP2. The amount of ATP was significantly decreased following vagotomy. It is concluded that UCP2 in the gastro-intestinal tract is regulated through vagal innervation and suggested to act as a free radical scavenger.

Department/s

  • Appetite Regulation
  • Department of Experimental Medical Science

Publishing year

2004

Language

English

Pages

217-222

Publication/Series

Nutritional Neuroscience

Volume

7

Issue

4

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Neurosciences
  • Basic Medicine

Keywords

  • ATP
  • SOD2
  • UCP2
  • Vagotomy

Status

Published

Research group

  • Appetite Regulation

ISBN/ISSN/Other

  • ISSN: 1476-8305