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Andreas Lindqvist

Andreas Lindqvist

Research engineer

Andreas Lindqvist

Ghrelin is a regulator of glucagon-like peptide 1 secretion and transcription in mice

Author

  • Andreas Lindqvist
  • Liliya Shcherbina
  • Ann-Helen Thorén Fischer
  • Nils Wierup

Summary, in English

The gut hormones ghrelin, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic peptide (GIP) have been intensively studied for their role in metabolism. It is, however, not well known whether the hormones interplay and regulate the secretion of each other. In this study, we studied the effect of ghrelin on GLP-1, GIP, and insulin secretion during an oral glucose tolerance test (OGTT) in mice. Intravenous administration of ghrelin caused increased GLP-1 secretion during the OGTT. On the other hand, ghrelin had no effect on circulating levels of glucose, insulin, and GIP. Furthermore, ghrelin treatment reduced proglucagon mRNA expression in GLUTag cells. The effect of ghrelin on GLP-1 secretion and proglucagon transcription was reinforced by the presence of GHS-R1a in human and mouse ileal L-cells, as well as in GLUTag cells. In summary, ghrelin is a regulator of GLP-1 secretion and transcription, and interfering with GHS-R1a signaling may be a way forward to enhance endogenous GLP-1 secretion in subjects with type 2 diabetes.

Department/s

  • Neuroendocrine Cell Biology
  • Department of Experimental Medical Science
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2017-06-19

Language

English

Publication/Series

Frontiers in Endocrinology

Volume

8

Issue

JUN

Document type

Journal article

Publisher

Frontiers Media S. A.

Topic

  • Endocrinology and Diabetes

Keywords

  • Ghrelin
  • GHS-R1a
  • Glucagon-like peptide 1
  • GLUTag cells
  • Oral glucose tolerance test

Status

Published

Research group

  • Neuroendocrine Cell Biology

ISBN/ISSN/Other

  • ISSN: 1664-2392