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Andreas Edsfeltdt

Andreas Edsfeldt

Researcher

Andreas Edsfeltdt

Soluble Urokinase Plasminogen Activator Receptor is Associated With Inflammation in the Vulnerable Human Atherosclerotic Plaque.

Author

  • Andreas Edsfeldt
  • Mihaela Nitulescu
  • Helena Grufman
  • Caitriona Grönberg
  • Ana Persson
  • Marie MN Nilsson
  • Margaretha Persson
  • Harry Björkbacka
  • Isabel Goncalves

Summary, in English

Recently, plasma soluble urokinase plasminogen activator receptor (suPAR) has gained interest as a marker of cardiovascular risk. suPAR is released through the cleavage of urokinase plasminogen activator receptor (uPAR), which is found in monocytes, activated T-lymphocytes and endothelial cells, all involved in atherosclerosis. suPAR levels have been well studied in plasma, but no studies have focused on suPAR in human atherosclerotic plaques. The aim of this study was to determine whether suPAR measured in the plaque is associated with symptomatic plaques and plaque inflammation.

Department/s

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Internal Medicine - Epidemiology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2012

Language

English

Pages

3305-3312

Publication/Series

Stroke; a journal of cerebral circulation

Volume

43

Issue

12

Document type

Journal article

Publisher

American Heart Association

Topic

  • Neurology

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1524-4628