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High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.

Author:
  • Sara Rattik
  • Maria Wigren
  • Harry Björkbacka
  • Gunilla Nordin Fredrikson
  • Bo Hedblad
  • Agneta Siegbahn
  • Eva Bengtsson
  • Alexandru Schiopu
  • Andreas Edsfeldt
  • Pontus Dunér
  • Helena Grufman
  • Isabel Goncalves
  • Jan Nilsson
Publishing year: 2015
Language: English
Pages: 222-228
Publication/Series: Arteriosclerosis, Thrombosis and Vascular Biology
Volume: 35
Issue: 1
Document type: Journal article
Publisher: Lippincott Williams Wilkins Hagerstown, MD

Abstract english

Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosclerotic plaques have received less attention. The present study aimed to investigate whether plasma levels of the smooth muscle cell growth factor epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and platelet-derived growth factor correlate with plaque phenotype and incidence of CEs.

Keywords

  • Cardiac and Cardiovascular Systems

Other

Published
  • Cardiovascular Research - Immunity and Athersosclerosis
  • Cardiovascular Research - Epidemiology
  • ISSN: 1524-4636

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