
Anders Rosengren
Postdoctoral research fellow

Metabolite profiling of LADA challenges the view of a metabolically distinct subtype
Author
Summary, in English
Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)-positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA fromtype 1 or type 2 diabetes. In this study, we examined whether metabolite profiling could help to distinguish LADA (n = 50) from type 1 diabetes (n = 50) and type 2 diabetes (n = 50). Of 123 identified metabolites, 99 differed between the diabetes types. However, no unique metabolite profile could be identified for any of the types. Instead, the metabolome varied along a C-peptide-driven continuum from type 1 diabetes via LADA to type 2 diabetes. LADA was more similar to type 2 diabetes than to type 1 diabetes. In a principal component analysis, LADA patients overlapping with type 1 diabetes progressed faster to insulin therapy than those overlapping with type 2 diabetes. In conclusion, we could not find any unique metabolite profile distinguishing LADA from type 1 and type 2 diabetes. Rather, LADA was metabolically an intermediate of type 1 and type 2 diabetes, with those patients closer to the former showing a faster progression to insulin therapy than those closer to the latter.
Department/s
- Diabetes - Molecular Metabolism
- Genomics, Diabetes and Endocrinology
- Department of Clinical Sciences, Malmö
- Diabetes - Islet Patophysiology
- Centre for Analysis and Synthesis
- EXODIAB: Excellence of Diabetes Research in Sweden
Publishing year
2017-04-01
Language
English
Pages
806-814
Publication/Series
Diabetes
Volume
66
Issue
4
Document type
Journal article
Publisher
American Diabetes Association Inc.
Topic
- Endocrinology and Diabetes
Status
Published
Research group
- Diabetes - Molecular Metabolism
- Genomics, Diabetes and Endocrinology
- Diabetes - Islet Patophysiology
ISBN/ISSN/Other
- ISSN: 0012-1797