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Anders Rosengren

Postdoctoral research fellow

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Aortic diameter at age 65 in men with newly diagnosed type 2 diabetes

Author

  • Soumia Taimour
  • Moncef Zarrouk
  • Jan Holst
  • Anders H. Rosengren
  • Leif Groop
  • Peter M. Nilsson
  • Anders Gottsäter

Summary, in English

Objectives. Type 2 diabetes mellitus has been linked to a decreased risk for abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA) development in men. The aim of this study was to evaluate if such an effect is detectable already around the time of diabetes diagnosis. Design. We cross-sectionally compared aortic diameter at ultrasound screening for AAA in 691 men aged 65 years with incipient or newly diagnosed type 2 diabetes (group A) with 18,262 65-year old control men without diabetes (group B). Results. Aortic diameter did not differ between groups (18.8[17.4–20.8] vs. 19.0[17.5–28.7] mm; p = 0.43). AAA prevalence was 2.5% in group A and 1.5% in group B (p = .010). In logistic regression taking group differences in body mass index (BMI), smoking, presence of atherosclerotic disease and hypertension into account, the difference in AAA prevalence was no longer significant (p = .15). Among men in group A, C-peptide (r = .093; p = .034), but not HbA1c (r = .060; p = .24) correlated with aortic diameter. Conclusion. Among 65 year old men aortic diameter and AAA prevalence do not differ between those with newly diagnosed type 2 diabetes and those without diabetes. Putative protective effects of type 2 diabetes mellitus against aortic dilatation and AAA development therefore probably occur later after diagnosis of diabetes.

Department/s

  • Vascular Diseases - Clinical Research
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2017-04-24

Language

English

Pages

202-206

Publication/Series

Scandinavian Cardiovascular Journal

Volume

51

Issue

4

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Endocrinology and Diabetes

Keywords

  • Abdominal aortic aneurysm
  • aortic diameter
  • screening
  • type 2 diabetes
  • ultrasound

Status

Published

Research group

  • Vascular Diseases - Clinical Research

ISBN/ISSN/Other

  • ISSN: 1401-7431