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Alexander Perfilyev

Assistant researcher

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The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.

Author

  • I Dahlman
  • I Sinha
  • H Gao
  • D Brodin
  • A Thorell
  • M Rydén
  • D P Andersson
  • J Henriksson
  • Alexander Perfilyev
  • Charlotte Ling
  • K Dahlman-Wright
  • P Arner

Summary, in English

Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many small fat cells) in post-obesity.

Department/s

  • Diabetes - Epigenetics
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2015

Language

English

Pages

910-919

Publication/Series

International Journal of Obesity

Volume

39

Issue

6

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Nutrition and Dietetics

Status

Published

Research group

  • Diabetes - Epigenetics

ISBN/ISSN/Other

  • ISSN: 1476-5497