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Alexander Perfilyev

Assistant researcher

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Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes

Author

  • Silja Schrader
  • Alexander Perfilyev
  • Mats Martinell
  • Sonia García-Calzón
  • Charlotte Ling

Summary, in English

Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials & methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate <5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685) and SC4MOL (cg05119988). Differential methylation of two sites related to cholesterol biosynthesis and immune response, cg17901584 (DHCR24) and cg23011663 (ARIH2), were replicated in ANDiU. Conclusion: Statin therapy associates with epigenetic modifications in T2D patients.

Department/s

  • Diabetes - Epigenetics
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2021-06-01

Language

English

Pages

919-925

Publication/Series

Epigenomics

Volume

13

Issue

12

Document type

Journal article

Publisher

Future Medicine Ltd.

Topic

  • Endocrinology and Diabetes

Keywords

  • cardiovascular disease
  • causal mediation analyses
  • DNA methylation
  • epigenetics
  • HDL
  • LDL
  • pharmacoepigenetics
  • statins
  • therapy
  • Type 2 diabetes

Status

Published

Research group

  • Diabetes - Epigenetics

ISBN/ISSN/Other

  • ISSN: 1750-1911