Alexander Perfilyev
Assistant researcher
Publications
Displaying of publications. Sorted by year, then title.
Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns, Which Associate With Future Diabetic Complications
Silja Schrader, Alexander Perfilyev, Emma Ahlqvist, Leif Groop, Allan Vaag, et al.
(2022) Diabetes Care, 45 p.1621-1630
Journal articleGlucocorticoids and glucolipotoxicity alter the DNA methylome and function of human EndoC-βH1 cells
Cristiane Dos Santos, Alexandros Karagiannopoulos, Alex Rafacho, Alexander Perfilyev, Lena Eliasson, et al.
(2022) Life Sciences, 307
Journal articleStatin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes
Silja Schrader, Alexander Perfilyev, Mats Martinell, Sonia García-Calzón, Charlotte Ling
(2021) Epigenomics, 13 p.919-925
Journal articleVPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
Cajsa Davegårdh, Johanna Säll, Anna Benrick, Christa Broholm, Petr Volkov, et al.
(2021) Nature Communications, 12
Journal articleLifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring
Josefine Jönsson, Kristina M. Renault, Sonia García-Calzón, Alexander Perfilyev, Angela C. Estampador, et al.
(2021) Diabetes, 70 p.854-866
Journal articleSerum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids
Vanessa D. de Mello, Ratika Sehgal, Ville Männistö, Anton Klåvus, Emma A Nilsson, et al.
(2021) Liver International, 41 p.754-763
Journal articleDifferential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes
Emma Nilsson, Magdalena Vavakova, Alexander Perfilyev, Johanna Säll, Per-Anders Jansson, et al.
(2021) Diabetes, 70 p.2402-2418
Journal articleEpigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men
Christa Broholm, Rasmus Ribel-Madsen, Line Hjort, Anders Henrik Olsson, Juliane Maria Dorothee Ahlers, et al.
(2020) Endocrine Research, 45 p.58-71
Journal articleEpigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes
Sonia García-Calzón, Alexander Perfilyev, Mats Martinell, Monta Ustinova, Sebastian Kalamajski, et al.
(2020) Science Translational Medicine, 12
Journal articleGlucolipotoxicity alters insulin secretion via epigenetic changes in human islets
Elin Hall, Josefine Jönsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, et al.
(2019) Diabetes, 68 p.1965-1974
Journal articleFasting unmasks differential fat and muscle transcriptional regulation of metabolic gene sets in low versus normal birth weight men
Linn Gillberg, Tina Rönn, Sine Wanda Jørgensen, Alexander Perfilyev, Line Hjort, et al.
(2019) EBioMedicine, 47 p.341-351
Journal articleLiver DNA methylation of FADS2 associates with FADS2 genotypex 06 Biological Sciences 0604 Genetics
Paula Walle, Ville Männistö, Vanessa Derenji De Mello, Maija Vaittinen, Alexander Perfilyev, et al.
(2019) Clinical Epigenetics, 11
Journal articleEpigenome-wide association study of incident type 2 diabetes in a British population : EPIC-Norfolk study
Alexia Cardona, Felix R. Day, John R.B. Perry, Marie Loh, Audrey Y. Chu, et al.
(2019) Diabetes, 68 p.2315-2326
Journal articleA Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome
Milana Kokosar, Anna Benrick, Alexander Perfilyev, Emma Nilsson, Thomas Källman, et al.
(2018) Scientific Reports, 8
Journal articleSex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels
Sonia García-Calzón, Alexander Perfilyev, Vanessa D. de Mello, Jussi Pihlajamäki, Charlotte Ling
(2018) The Journal of clinical endocrinology and metabolism, 103 p.4395-4408
Journal articleDNA methylation patterns in human adipose tissue in relation to diet and type 2 diabetes
Alexander Perfilyev
(2018) Lund University, Faculty of Medicine Doctoral Dissertation Series, 2018
DissertationDiabetes medication associates with DNA methylation of metformin transporter genes in the human liver
Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa de Mello, Emma A Nilsson, et al.
(2017) Clinical Epigenetics, 9 p.1-9
Journal articleImpact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue : A randomized controlled trial
Alexander Perfilyev, Ingrid Dahlman, Linn Gillberg, Fredrik Rosqvist, David Iggman, et al.
(2017) American Journal of Clinical Nutrition, 105 p.991-1000
Journal articleHuman liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action
Vanessa de Mello, Ashok Matte, Alexander Perfilyev, Ville Männistö, Tina Rönn, et al.
(2017) Epigenetics, 12 p.287-295
Journal articleAbnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects
Cajsa Davegårdh, Christa Broholm, Alexander Perfilyev, Tora Henriksen, Sonia García-Calzón, et al.
(2017) BMC Medicine, 15 p.1-27
Journal articleEpigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver
Madhusudhan Bysani, Alexander Perfilyev, Vanessa de Mello, Tina Rönn, Emma Nilsson, et al.
(2017) Epigenomics, 9 p.105-122
Journal articleHuman adipogenesis is associated with genome-wide DNA methylation and gene-expression changes
Christa Broholm, Anders Henrik Olsson, Alexander Perfilyev, Linn Gillberg, Ninna Schiøler Hansen, et al.
(2016) Epigenomics, 8 p.1601-1617
Journal articleEpigenetic programming of adipose-derived stem cells in low birthweight individuals
Christa Broholm, Anders H. Olsson, Alexander Perfilyev, Ninna S. Hansen, Maren Schrölkamp, et al.
(2016) Diabetologia, 59 p.2664-2673
Journal articleDNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk
Tasnim Dayeh, Tiinamaija Tuomi, Peter Almgren, Alexander Perfilyev, Per Anders Jansson, et al.
(2016) Epigenetics, 11 p.482-488
Journal articleAdipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.
Linn Gillberg, Alexander Perfilyev, Charlotte Brøns, Martin Thomasen, Louise G Grunnet, et al.
(2016) Diabetologia, 59 p.799-812
Journal articleEpigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome
Milana Kokosar, Anna Benrick, Alexander Perfilyev, Romina Fornes, Emma A Nilsson, et al.
(2016) Scientific Reports, 6
Journal articleEpigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.
Emma A Nilsson, Ashok Matte, Alexander Perfilyev, Vanessa D de Mello, Pirjo Käkelä, et al.
(2015) Journal of Clinical Endocrinology and Metabolism, 100 p.1491-1501
Journal articleThe fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.
I Dahlman, I Sinha, H Gao, D Brodin, A Thorell, et al.
(2015) International Journal of Obesity, 39 p.910-919
Journal articleImpact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood.
Tina Rönn, Petr Volkov, Linn Gillberg, Milana Kokosar, Alexander Perfilyev, et al.
(2015) Human Molecular Genetics, 24 p.3792-3813
Journal articleGenome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.
Elisabet Agardh, Annika Lundstig, Alexander Perfilyev, Petr Volkov, Tove Freiburghaus, et al.
(2015) BMC Medicine, 13
Journal articleAltered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes.
Emma A Nilsson, Per Anders Jansson, Alexander Perfilyev, Petr Volkov, Maria Pedersen, et al.
(2014) Diabetes, 63 p.2962-2976
Journal article