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Alaitz Poveda

Postdoctoral fellow

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The heritable basis of gene–environment interactions in cardiometabolic traits

Author

  • Alaitz Poveda
  • Yan Chen
  • Anders Brändström
  • Elisabeth Engberg
  • Göran Hallmans
  • Ingegerd Johansson
  • Frida Renström
  • Azra Kurbasic
  • Paul W. Franks

Summary, in English

Aims/hypothesis: Little is known about the heritable basis of gene–environment interactions in humans. We therefore screened multiple cardiometabolic traits to assess the probability that they are influenced by genotype–environment interactions. Methods: Fourteen established environmental risk exposures and 11 cardiometabolic traits were analysed in the VIKING study, a cohort of 16,430 Swedish adults from 1682 extended pedigrees with available detailed genealogical, phenotypic and demographic information, using a maximum likelihood variance decomposition method in Sequential Oligogenic Linkage Analysis Routines software. Results: All cardiometabolic traits had statistically significant heritability estimates, with narrow-sense heritabilities (h2) ranging from 24% to 47%. Genotype–environment interactions were detected for age and sex (for the majority of traits), physical activity (for triacylglycerols, 2 h glucose and diastolic BP), smoking (for weight), alcohol intake (for weight, BMI and 2 h glucose) and diet pattern (for weight, BMI, glycaemic traits and systolic BP). Genotype–age interactions for weight and systolic BP, genotype–sex interactions for BMI and triacylglycerols and genotype–alcohol intake interactions for weight remained significant after multiple test correction. Conclusions/interpretation: Age, sex and alcohol intake are likely to be major modifiers of genetic effects for a range of cardiometabolic traits. This information may prove valuable for studies that seek to identify specific loci that modify the effects of lifestyle in cardiometabolic disease.

Department/s

  • Genetic and Molecular Epidemiology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2017

Language

English

Pages

442-452

Publication/Series

Diabetologia

Volume

60

Issue

3

Document type

Journal article

Publisher

Springer

Topic

  • Medical Genetics
  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems

Keywords

  • Cardiometabolic traits
  • Environment
  • Extended pedigrees
  • Gene
  • Heritability
  • Interaction
  • VIKING study

Status

Published

Research group

  • Genetic and Molecular Epidemiology

ISBN/ISSN/Other

  • ISSN: 0012-186X