
Alaitz Poveda
Postdoctoral fellow

Lifestyle and precision diabetes medicine : will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?
Author
Summary, in English
Precision diabetes medicine, the optimisation of therapy using patient-level biomarker data, has stimulated enormous interest throughout society as it provides hope of more effective, less costly and safer ways of preventing, treating, and perhaps even curing the disease. While precision diabetes medicine is often framed in the context of pharmacotherapy, using biomarkers to personalise lifestyle recommendations, intended to lower type 2 diabetes risk or to slow progression, is also conceivable. There are at least four ways in which this might work: (1) by helping to predict a person’s susceptibility to adverse lifestyle exposures; (2) by facilitating the stratification of type 2 diabetes into subclasses, some of which may be prevented or treated optimally with specific lifestyle interventions; (3) by aiding the discovery of prognostic biomarkers that help guide timing and intensity of lifestyle interventions; (4) by predicting treatment response. In this review we overview the rationale for precision diabetes medicine, specifically as it relates to lifestyle; we also scrutinise existing evidence, discuss the barriers germane to research in this field and consider how this work is likely to proceed.
Department/s
- Genetic and Molecular Epidemiology
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
Publishing year
2017-01-25
Language
English
Pages
784-792
Publication/Series
Diabetologia
Volume
60
Issue
5
Document type
Journal article review
Publisher
Springer
Topic
- Endocrinology and Diabetes
Keywords
- Biomarkers
- Lifestyle
- Precision medicine
- Type 2 diabetes
Status
Published
Research group
- Genetic and Molecular Epidemiology
ISBN/ISSN/Other
- ISSN: 0012-186X