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Alaitz Poveda

Postdoctoral fellow

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Lifestyle and precision diabetes medicine : will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?

Author

  • Paul W. Franks
  • Alaitz Poveda

Summary, in English

Precision diabetes medicine, the optimisation of therapy using patient-level biomarker data, has stimulated enormous interest throughout society as it provides hope of more effective, less costly and safer ways of preventing, treating, and perhaps even curing the disease. While precision diabetes medicine is often framed in the context of pharmacotherapy, using biomarkers to personalise lifestyle recommendations, intended to lower type 2 diabetes risk or to slow progression, is also conceivable. There are at least four ways in which this might work: (1) by helping to predict a person’s susceptibility to adverse lifestyle exposures; (2) by facilitating the stratification of type 2 diabetes into subclasses, some of which may be prevented or treated optimally with specific lifestyle interventions; (3) by aiding the discovery of prognostic biomarkers that help guide timing and intensity of lifestyle interventions; (4) by predicting treatment response. In this review we overview the rationale for precision diabetes medicine, specifically as it relates to lifestyle; we also scrutinise existing evidence, discuss the barriers germane to research in this field and consider how this work is likely to proceed.

Department/s

  • Genetic and Molecular Epidemiology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2017-01-25

Language

English

Pages

784-792

Publication/Series

Diabetologia

Volume

60

Issue

5

Document type

Journal article review

Publisher

Springer

Topic

  • Endocrinology and Diabetes

Keywords

  • Biomarkers
  • Lifestyle
  • Precision medicine
  • Type 2 diabetes

Status

Published

Research group

  • Genetic and Molecular Epidemiology

ISBN/ISSN/Other

  • ISSN: 0012-186X