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Åke Lernmark

Principal investigator

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A prospective analysis of antibodies reacting with pancreatic islet cells in insulin-dependent diabetic children

Author

  • Å Lernmark
  • B. Hägglöf
  • Z. Freedman
  • J. Irvine
  • J. Ludvigsson
  • G. Holmgren

Summary, in English

Islet cell cytoplasmic and cell surface antibodies along with other autogenic tissue antibodies were determined prospectively from the day of diagnosis of insulin-dependent diabetes in a group of children and adolescents. Prior to the initiation of insulin therapy 30 out of 33 were antibody-positive, 67% having islet cytoplasmic antibodies and 67% islet cell surface antibodies. Among 74 age- and sex-matched non-diabetic individuals 1% had islet cell cytoplasmic antibodies and 3% had islet cell surface antibodies. A prospective analysis in 17 patients showed a diminishing prevalence of islet cell antibodies with increasing duration of diabetes. Islet cell cytoplasmic or cell surface antibodies were found independently of each other or in combination and with various patterns of persistence. The results indicate a strong association of islet cell antibodies with the onset of insulin-dependent diabetes in childhood and adolescence.

Publishing year

1981-01-01

Language

English

Pages

471-474

Publication/Series

Diabetologia

Volume

20

Issue

4

Document type

Journal article

Publisher

Springer

Keywords

  • autoimmunity
  • Insulin-dependent diabetes
  • islet cell antibodies
  • islet cell surface antobodies

Status

Published

ISBN/ISSN/Other

  • ISSN: 0012-186X