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Åke Lernmark

Principal investigator

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Autoimmunity in insulin-dependent diabetes mellitus

Author

  • Jørn Nerup
  • Ake Lernmark

Summary, in English

Genetic susceptibility, environmental factors and immune mechanisms are implicated in the pathogenesis and etiology of insulindependent diabetes mellitus. The onset of the disease is associated with a major loss of beta cells, and inflammatory cells may be seen in and around the islets of Langerhans. Insulin-dependent diabetes is often associated with autoimmune endocrinopathies. Antipancreatic cell-mediated autoimmunity is found predominantly in young patients with insulin-dependent diabetes of recent onset as are antibodies reactive with cytoplasmic components or cell surface determinants of islet cells. Antibodies reactive with live islet cells may mediate complement-dependent cytotoxicity. The antigen(s) in the islet cells remain(s) to be identified and characterized. Further studies will be necessary to determine whether autoimmunity is the cause of beta-cell destruction or whether it is a consequence of damages caused by exogenous agents in susceptible persons.

Publishing year

1981-01-01

Language

English

Pages

135-141

Publication/Series

The American journal of medicine

Volume

70

Issue

1

Document type

Journal article

Publisher

Elsevier

Status

Published

ISBN/ISSN/Other

  • ISSN: 0002-9343