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Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes.

Author:
  • J Yang
  • Åke Lernmark
  • U M Uusitalo
  • K F Lynch
  • R Veijola
  • C Winkler
  • Helena Larsson
  • M Rewers
  • J-X She
  • A G Ziegler
  • O G Simell
  • W A Hagopian
  • B Akolkar
  • J P Krischer
  • K Vehik
Publishing year: 2014
Language: English
Pages: 1491-1496
Publication/Series: International Journal of Obesity
Volume: 38
Issue: 12
Document type: Journal article
Publisher: Nature Publishing Group

Abstract english

Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.Methods:Repeated measures of weight and height were collected from 5969 children 2-4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index (BMI) of 25 and 30 kg m(-)(2) at age 18.Results:The average BMI was comparable across specific HLA genotypes at every age point. The proportion of overweight was not different by HLA, but percent obesity varied by age with a decreasing trend among DQ2/8 carriers (P for trend=0.0315). A multivariable regression model suggested DQ2/2 was associated with higher obesity risk at age 4 (odds ratio, 2.41; 95% confidence interval, 1.21-4.80) after adjusting for the development of islet autoantibody and/or type 1 diabetes.Conclusions:The HLA-DQ2/2 genotype may predispose to obesity among 2-4-year-old children with genetic risk for type 1 diabetes.International Journal of Obesity advance online publication, 29 April 2014; doi:10.1038/ijo.2014.55.

Keywords

  • Nutrition and Dietetics

Other

Published
  • Diabetes and Celiac Unit
  • Paediatric Endocrinology
  • ISSN: 1476-5497
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

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+46 70 616 47 79

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Jan Waldenströms gata 35, Malmö

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Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00