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Åke Lernmark

Principal investigator

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Autoimmune (type 1) diabetes

Author

  • Ahmed Delli
  • Åke Lernmark

Editor

  • Noel Rose
  • Ian MacKay

Summary, in English

Autoimmune (type 1) diabetes (AI-DM) is a multistage disorder. Children are born genetically predisposed to putative environmental exposures. These trigger an aggressive, selective and chronic autoimmune response against the pancreatic islet beta cells. This stage is marked by autoantibodies against insulin, glutamic acid decarboxylase (GAD65), IA-2 and the ZnT8 transporter. Progression to clinical onset of diabetes is highly variable but the time to onset is shortened with an increased number of islet autoantibodies. Both islet autoantibodies and diabetes are associated with HLA-DQ on chromosome 6. More than 50 non-HLA genetic factors, mostly associated with the human immune response also contribute. It remains to be clarified to what extent HLA-DQ and the non-HLA genes contribute to the initiation of the chronic islet autoimmunity, progression to diabetes, or both. Insulin replacement therapy is still the only treatment as all attempts to halt the loss of beta cells by immunosuppression or immune modulation have failed so far.

Department/s

  • Diabetes and Celiac Unit
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2013

Language

English

Pages

575-585

Publication/Series

The Autoimmune Diseases

Document type

Book chapter

Publisher

Academic Press

Topic

  • Endocrinology and Diabetes

Keywords

  • Diabetes
  • type 1
  • Autoimmune diabetes
  • Islet autoimmunity
  • Islet autoantibodies
  • Insulitis.

Status

Published

Research group

  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISBN: 0123849292