Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Åke Lernmark

Principal investigator

Default user image.

Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset.

Author

  • L M Bekris
  • C Shephard
  • M Peterson
  • J Hoehna
  • B Van Yserloo
  • E Rutledge
  • F Farin
  • T J Kavanagh
  • Åke Lernmark

Summary, in English

Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic beta cell destruction involving auto-reactive T-cells, pro-inflammatory cytokines, reactive oxygen species (ROS) and loss of insulin. Monozygotic twin studies show a 20-60% concordance with T1D indicating there may be an environmental component to the disease. Glutathione (GSH) is the major endogenous antioxidant produced by the cell. GSH participates directly in the neutralization of free radicals and plays a role in the immune response. Glutathione-s-transferases (GSTs) conjugate GSH to free-radicals or xenobiotics. GST activity depletes GSH levels and may either detoxify or enhance the toxicity of a compound. Glutathione-s-transferase mu 1 (GSTM1) and glutathione-s-transferase theta 1 (GSTT1) have polymorphic homozygous deletion (null) genotypes resulting in complete absence of enzyme activity. GSTM1 and GSTT1 null genotypes in Caucasian populations have frequencies of approximately 40-60% and 15-20%, respect

Publishing year

2005

Language

English

Pages

567-575

Publication/Series

Autoimmunity

Volume

38

Issue

8

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Rheumatology and Autoimmunity

Keywords

  • glutathione-s-transferase
  • Type 1 diabetes
  • polymorphism
  • GSTT1
  • GSTM1
  • age-at-onset

Status

Published

ISBN/ISSN/Other

  • ISSN: 0891-6934