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Åke Lernmark

Principal investigator

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The feasibility of salivary sample collection in an international pediatric cohort : The the TEDDY study

Author

  • Roswith Roth
  • Judith Baxter
  • Kendra Vehik
  • Diane Hopkins
  • Michael Killian
  • Patricia Gesualdo
  • Marie Jessica Melin
  • Barbara Simell
  • Elisabeth Strauss
  • Åke Lernmark
  • Suzanne Bennett Johnson

Summary, in English

Saliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection to assess cortisol level as a physiologic marker of stress. Saliva was collected using Sorbettes from subjects at 3.5, 4.5, and 5.5 years of age. Parents collected a morning sample, and staff collected pre- and post-blood draw samples. Feasibility was assessed based on protocol completion, adherence with instructions, factors affecting adherence, and sufficiency of saliva sample for cortisol determination. Collection of saliva samples in a diverse pediatric population is feasible. Establishing non-invasive and acceptable methods for collecting physiological parameters of stress will allow better exploration of determinants of health in this important population.

Department/s

  • Diabetes and Celiac Unit
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2017-07-01

Language

English

Pages

658-667

Publication/Series

Developmental Psychobiology

Volume

59

Issue

5

Document type

Journal article

Publisher

John Wiley and Sons

Topic

  • Public Health, Global Health, Social Medicine and Epidemiology

Keywords

  • adherence
  • methodological feasibility
  • multi-center international
  • pediatric cohort study
  • salivary collection
  • salivary cortisol

Status

Published

Research group

  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISSN: 0012-1630