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Åke Lernmark

Principal investigator

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Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes

Author

  • H-S Lee
  • T. Briese
  • C. Winkler
  • M. Rewers
  • E. Bonifacio
  • H. Hyoty
  • M. Pflueger
  • O. Simell
  • J. X. She
  • W. Hagopian
  • Åke Lernmark
  • B. Akolkar
  • J. P. Krischer
  • A. G. Ziegler

Summary, in English

Viruses are candidate causative agents in the pathogenesis of autoimmune (type 1) diabetes. We hypothesised that children with a rapid onset of type 1 diabetes may have been exposed to such agents shortly before the initiation of islet autoimmunity, possibly at high dose, and thus study of these children could help identify viruses involved in the development of autoimmune diabetes. We used next-generation sequencing to search for viruses in plasma samples and examined the history of infection and fever in children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study who progressed to type 1 diabetes within 6 months from the appearance of islet autoimmunity, and in matched islet-autoantibody-negative controls. Viruses were not detected more frequently in plasma from rapid-onset patients than in controls during the period surrounding seroconversion. In addition, infection histories were found to be similar between children with rapid-onset diabetes and control children, although episodes of fever were reported less frequently in children with rapid-onset diabetes. These findings do not support the presence of viraemia around the time of seroconversion in young children with rapid-onset type 1 diabetes.

Department/s

  • Diabetes and Celiac Unit
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2013

Language

English

Pages

1705-1711

Publication/Series

Diabetologia

Volume

56

Issue

8

Document type

Journal article

Publisher

Springer

Topic

  • Endocrinology and Diabetes

Keywords

  • GB virus C
  • Human herpes virus 6
  • Human rhinovirus C
  • Infections
  • Islet
  • autoimmunity
  • Next-generation deep sequencing
  • Parvovirus B19
  • TEDDY
  • study
  • Type 1 diabetes mellitus

Status

Published

Research group

  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISSN: 1432-0428