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Åke Lernmark

Principal investigator

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Glucose stimulates the biosynthesis of a human pancreatic islet cell protein detected by an antiserum against the human erythrocyte glucose transporter

Author

  • Steinunn Bækkeskov
  • Åke Lernmark

Summary, in English

An antiserum raised against the purified human erythrocyte glucose transporter specifically immunoprecipitated a major protein of Mr36 000 and a minor protein of Mr 58 000 from human pancreatic islets. The biosynthetic incorporation of [35S]methionine into the 36-kDa protein increased 2-3 fold in 16 mM D-glucose with 0.1 mM IBMX as compared to islets incubated in 3 mM D-glucose either with or without IBMX. D-Glucose tested without or with IBMX had no effect on the biosynthesis of the 58-kDa protein. The 36-kDa protein was also detected in rat islets and rat islet tumor cells. It is suggested that this protein may represent a D-glucose and cAMP sensitive component of a glucose transport or glucose binding protein in the pancreatic β-cell.

Publishing year

1983-07-04

Language

English

Pages

331-335

Publication/Series

FEBS Letters

Volume

157

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Keywords

  • 3-Isobutyl-1-methylxanthine
  • Glucose regulation
  • Glucose transport
  • Human erythrocyte glucose transporter
  • Human pancreatic islet
  • β-Cell protein

Status

Published

ISBN/ISSN/Other

  • ISSN: 0014-5793