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Åke Lernmark

Principal investigator

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Autoimmunity of diabetes

Author

  • A. Lernmark
  • H. Barmeier
  • S. Dube
  • W. Hagopian
  • A. Karlsen
  • R. Wassmuth

Summary, in English

Mechanisms underlying the etiology and pathogenesis of insulin-dependent diabetes mellitus (IDDM) are reviewed. Its natural history and associated autoimmune phenomena indicate that IDDM is a systemic disorder resulting in a specific disappearance of pancreatic β cells. Genetic aspects of the disorder include its linkage to HLA class II gene loci, although the manner in which this produces autoimmunity is unclear, and a second gene outside the HLA complex could be more important. The roles of environmental influences, including viruses, also require clarification. Further studies on the molecular biology of the immune response against β cell specific antigens are required.

Publishing year

1991-09-30

Language

English

Publication/Series

Endocrinology and Metabolism Clinics of North America

Volume

20

Issue

3

Document type

Journal article review

Publisher

W.B. Saunders

Status

Published

ISBN/ISSN/Other

  • ISSN: 0889-8529