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Åke Lernmark

Principal investigator

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Interleukin-1β regulation of islet and thyroid autoimmunity in the BB rat

Author

  • Sarah Vertrees
  • Cindy A. Wilson
  • Roel Ubungen
  • Deborah Wilson
  • Denis G. Baskin
  • Bert Toivola
  • Cindy Jacobs
  • Norman Boiani
  • Paul Baker
  • Åke Lernmark

Summary, in English

Daily injections of high dose human recombinant interleukin-1β (IL-1β) accelerated the onset of both insulin-dependent diabetes mellitus and lymphocytic thyroiditis in genetically prone BB rats. In diabetes-resistant BB rats, high dose IL-1β failed to induce diabetes. Additionally, the presence of neutralizing IL-1β antibodies in these rats strongly correlated with inhibition of lymphocytic thyroiditis. Since low dose IL-1β protects diabetes-prone rats from IDDM, we conclude that IL-1β is a potent modulator of autoimmune diabetes and thyroid disease in genetically susceptible rats.

Publishing year

1991-01-01

Language

English

Pages

717-732

Publication/Series

Journal of Autoimmunity

Volume

4

Issue

5

Document type

Journal article

Publisher

Elsevier

Status

Published

ISBN/ISSN/Other

  • ISSN: 0896-8411