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Åke Lernmark

Principal investigator

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Induction of donor-specific tolerance to islet allografts in nonhuman primates.

Author

  • LK Gaur
  • E Kennedy
  • Y Nitta
  • GT Nepom
  • KA Nelson
  • M Allen
  • Åke Lernmark

Summary, in English

Pancreatic tissue grafting is by far the most physiological therapeutic solution to the insulin deficiency of diabetes. Recent clinical trials have indicated somewhat successful use of nonsteroidal immunosuppressive regimens and a successful nonhuman primate trial using CD154 for costimulation blockade was reported. However, these protocols need to be replaced with safe and efficacious ones in which long-term allotolerance would make these treatments routine in a clinical setting. With the specific objective of testing whether peripheral infusions of stem cells or stem cell fractions in conjunction with islet allografting would induce allograft tolerance, we have established a macaque diabetic model. The macaques were rendered diabetic by streptozotocin and required daily doses of insulin to maintain lower blood glucose levels. The diabetic macaques then received islets and stem cells from unrelated and MHC-mismatched donors without any immunosuppression. In our initial analysis, 5 of

Department/s

  • Diabetes and Celiac Unit

Publishing year

2002

Language

English

Pages

194-198

Publication/Series

Annals of the New York Academy of Sciences

Volume

958

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes and Celiac Unit

ISBN/ISSN/Other

  • ISSN: 0077-8923