Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.

Author:
  • J Graham
  • WA Hagopian
  • I Kockum
  • LS Li
  • CB Sanjeevi
  • RM Lowe
  • JB Schaefer
  • M Zarghami
  • HL Day
  • Mona Landin-Olsson
  • JP Palmer
  • M Janer-Villanueva
  • L Hood
  • G Sundkvist
  • Åke Lernmark
  • N Breslow
  • G Dahlquist
  • G Blohme
Publishing year: 2002
Language: English
Pages: 1346-1355
Publication/Series: Diabetes
Volume: 51
Issue: 5
Document type: Journal article
Publisher: American Diabetes Association Inc.

Abstract english

Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, and islet cells were determined by logistic regression analysis in 971 incident patients with type 1 diabetes and 702 control subjects aged 0-34 years. GADAs were associated with HLA-DQ2 in young but not in older patients (P = 0.009). Autoantibodies to insulin were negatively associated with age (P < 0.0001) but positively associated with DQ8 (P = 0.03) and with INS VNTR (P = 0.04), supporting possible immune tolerance induction. ICA512/IA-2 were negatively associated with age (P < 0.0001) and with DQ2 (P < 0.0001) but positively associated with DQ8 (P = 0.04). Males were more likely than females to be negative for GADA (P < 0.0001), autoantibodies to islet cells (P = 0.04), and all four autoantibody markers (P = 0.004). The CTLA-4 3' end microsatellite marker was not associated with any of the autoantibodies. We conclude that age and genetic factors such as HLA-DQ and INS VNTR need to be combined with islet autoantibody markers when evaluating the risk for type 1 diabetes development.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Diabetes and Celiac Unit
  • ISSN: 1939-327X
E-mail: ake [dot] lernmark [at] med [dot] lu [dot] se

Principal investigator

Diabetes and Celiac Unit

+46 40 39 19 01

+46 70 616 47 79

60:11:015

Jan Waldenströms gata 35, Malmö

33

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00